Iv'e been taking Latuda for over a year now. I take 125mg with Lamictal 200mg. I feel like a "normal" person again. I was suicidal and was hospitalized, I was in a rough state before we found the right dose for me. I haven't had any side effect other than lethargy. Its really important that you take Latuda with 350 calories. I was taking it with breakfast but it seems to be making me too sedated at work (I've been falling asleep) so I am going to switch it to dinner time and hopefully it will make me sleep more deeply. Good luck, I personally think its a great drug.