I might be wrong, but I get the queasy feeling reading these threads that posters in this section are only trying drugs, they are here because their drugs aren't working and yet they are not trying new things. There are so many non-drugs things to try for depression! I have the feeling that some people are waiting for their doctors to figure it out for them.

"DrJohn:
To me, and in this context, it means you've tried multiple treatment options -- whether it be psychotherapy, meds, ECT, TMS, whatever -- over a period of years and despite your (and your professionals') best efforts and multiple tries on different treatments (whether it be with different therapists, therapies, meds, etc.), very little has touched your depression. You are still depressed. It doesn't seem to have responded much to anything."

That's my definition. I'm going to close this thread to encourage you all to start new threads here on the topics of the most interest to you...