I started zoloft monotherapy in june after months of awful depression and anxiety. It made me somewhat manic in the beginning (which was honestly a very welcome relief and manageable since it was for a short time / not too bad), then I felt great, then once I got to 75 mg. a little too great. I decided to go off and tapered very very slowly...so slowly I didn't notice I was becoming depressed again until WAM - feeling suicidal. I'm now back on just 50mg and am doing really well so far...that's just my personal story (I'm BP II by the way, which I think makes a difference in cases like this...)