Hi Shy, it is always difficult if not impossible to know what someone else is thinking.....so since you seem hurt and confused I would ask her.
Since your friend has had so much tragedy in her life recently it may have absolutely nothing to do with you, she may just feel more connected with her other friends lately.
I would make your discussion about her and not about you! At this point in her life she may not want to hear that you are hurt, since she is hurting so much. I would tell her how much you miss her and tell her you know she has been through so much and you would like her to know you are there for her. Tell her you are never to busy to make time for her because you care about and love her!(do not mention other friends)
If this talk does not bring her around at all then maybe you should give her some time.
If she does not come around there may not be anything else you can say.
I know it may be difficult not to take this all personally, but seriously, maybe it is not about you at all!!