DEPLIN is a prescription at dosage levels 7.5 mg and 15 mg. You can get OTC L Methylfolate 1 mg on AMAZON, 100 capsules for $18. The only reason that DEPLIN requires prescription, in my opinion, is to protect PamLabs patent. You would have to take 15 of those 1mg capsules every day to get the dosage of DEPLIN. (A lot like Nexium now. You can get 20mg Nexium OTC but requires prescription for 40mg. Makes no sense. Buy OTC 20mg and take two. No doctor or prescription needed)

My doctor that just prescribed it for me didn't tell me anything about it except that it was a "vitamin". That was it. She knew I would go research it on the internet so didn't take the time to explain anything.

Why no blood test for folate? Because people with MTHFR will have normal levels of folate in the blood. There is no way to measure the amount of L Methylfolate available to produce seritonin, dopamine and norepinephrine.

In medical practice, it seems the only patients that get genetic testing ordered are women with multiple miscarriages. MTHFR is known to be associated with high fetal loss.

Some mutations of MTHFR can cause some pretty serious medical problems. Blood clots in legs, early coronary artery disease and stroke. So in limited cases, it might be important to know your MTHFR status.

The studies that have shown positive results with DEPLIN have been done without ever determining whether participants have the genetic mutation.

Read the results from this Fox News Report: Deplin: A 'medical food' that treats depression | Fox News

Since it is estimated that up to 70% of US population has at least one of the mutations, why bother with testing? Just give DEPLIN a try. I can't hurt anyone. There are no known side effects. No drug interactions. Can't overdose on it. If it helps, it helps. If it doesn't, just quit taking it. No withdrawal or tapering necessary.

Scientists and medical doctors do not agree whether the mechanism of MTHFR has anything to do with why DEPLIN works. Some studies say DEPLIN does nothing. But the sellers of DEPLIN say those studies are flawed because they didn't give enough L Methylfolate to participants. So the scientific basis of DEPLIN is in question. But the fact that is really does help depression when combined with an SSRI in some resistant depressions is not.

Hey. I have tried many obnoxious drugs that didn't work. Why not try an activated vitamin? I'm game.