Quote:
Originally Posted by zinco14532323
Those are clinical trials with placebo but they only last 6 to 8 weeks. Hardly enough time to tell. Real world results seem to tell a different story. I only know of one long term study that emulated clinical practice. The STAR*D. You can find criticism of that study too. I believe there is a very large international one going on now.
Here is a good article.
NIMH · Antidepressants: A complicated picture
The study below looked at all the clinical trials. It seems they are more effective the more severe the depression. The draw backs are 6 to 8 week double blind placebo trials that included the placebo wash out period. To me 6 to 8 weeks doesn't tell you much.
JAMA Network | JAMA | Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis |
Maybe but I was thinking of a study of a specific AD that lasted longer than 6-8 weeks. A study in which internal corporate documents pertaining to the study were either subpoenaed or leaked.
Yes indeed, the author points out some of the problems with that STAR*D study and you probably noticed one or two yourself.
Okay... I'll get back on topic now. I'm not afraid of ADs but I have much less faith in them now than I once had. And I also feel some resentment that the doctors who originally prescribed my AD did not mention withdrawal effects at all. Or what they so nicely call discontinuation syndrome these days
