I have taken indomethacin for pleurisy. When I had a second occurrence of pleurisy many years later I asked a nurse practitioner for indomethacin again (on account of its having been quick and immediate relief the previous time). She flat out refused on the basis that in her estimation the risk/benefit profile of indomethicin didn't warrant using it. She mentioned its high tendency to cause GI distress. She didn't go into kidney risk.