Yes well I can assure those that are contributing to this thread that I have in fact been dealing with the issue for decades. Blood tests and addressing deficiencies etc has all been tried and done many many years ago. Although diet and lifestyle plays a role in mood it appears to be driven by biology in my case. As was said it is a medical condition.

@ zinco I have finished with the ssri and ssnri meds. And am moving to the tricyclic medications.