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Old Nov 14, 2014, 03:57 PM
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Member Since: Feb 2014
Location: Michigan
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Quote:
Originally Posted by lonely-and-sad View Post
The problem in Australia is that it is only available (as zyban) as a stop smoking aid and prescribed for 3 months. I might be able to get it by alternative means if you follow what I am suggesting. @ zinco do you know much about agomolatine? Strangely that is available in the States by alternative means but is actually available here and is what I was going to try next.
I have not heard of agomolatine. Can't find much even googling it.

Agomelatine (Valdoxan/ Thymanax): risk of dose-related hepatotoxicity and liver failure ? updated warnings and monitoring guidance. : MHRA

Liver toxicity problems it looks like.

Quote:
Agomelatine is an antidepressant indicated for the treatment of major depressive episodes in adults. Agomelatine is a melatonin MT1 and MT2 receptor agonist, and antagonist at the serotonin 5-HT2C receptor, thereby increasing levels of dopamine and noradrenaline in areas of the brain involved in mood control.
Following several reports of liver injury, including hepatic failure, all available data on elevated transaminases and hepatotoxicity with agomelatine use have been reviewed.
In the US when a med is not approved by the FDA but maybe is approved in Europe you can sometimes get a waiver to use it from the FDA. I did this once with reboxotine. I wonder why wellbutrin is not approved in Australia.

If you don't want SSRI's or SSNRI's and can't get wellbutrin your choices are limited. I have taken Remeron and Trazadone but only for sleep. I don't think they help my depression much.

You may try supplements like
5HTP
L tryptophan
L methyfolate
St. Johns Wort
Fish Oil
Melatonin
Vitamin D
B vitamins.

All you can take with an antidepressant except 5HTP. 5HTP you would want to be careful with if taking an AD.
__________________
The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back