I agree with Hooligan, you need to find out exactly where he is at mentally before you will know how to best help him. Will he allow you to talk to his Therapist or Pdoc? Can you go with him? Is there a specific time / thing you can think that marks when this started that might indicate whether its due to either depression or a medication change?

If it is depression or medication that is causing these issues, it is definitely something that should be discussed with his Pdoc, hence why it would be good for you to be able to attend. If he is hesitant to the idea of you going, you could reassure him by telling him you want to be there so you can understand how to better help him. If he is still hesitant, perhaps he would be more comfortable with you talking to his Pdoc privately.

I know at times I have given my wife absolute hell when I have been in a depressed state. I have not been able to get out of bed, not eat, not face people, the phone, appointments or any situation that causes me stress. During these times I have pushed the boundaries of our relationship in a "call for help", being in so much pain that I "shared" the pain with my partner to show them how much I am hurting. While a horrible thing to do, and I am ashamed to admit it, I can relate to the whole staying in bed and letting things get to the point where it endangers your relationship.

Don't give up yet, but see if you can get the lines of communication open with him and inturn with his Pdoc and Therapist so you can help him better.

I wish you all the best