Thanks Zinco-

The coating on the Pristiq tablet, from what I read, makes it able to pass through the stomach w/o breaking down & going into the blood stream there. There are NO directions by the manufacturer on how to taper off their lowest dose, 50 mg. Fetzima caused some noticable mania in me , and the pdoc wanted me off of this immediately.

The only reason I ended up on Pristiq was I have no insurance and Cymbalta came off patent, so my clinic was not receiving samples. The "at cost" price from a pharmacist who was willing to sell it to me, was ~ $170 per month..I could not afford it.

I am tired of spinning the "wheel" for an effective AD.

Is it OK if I PM you?