Way back in the day when I was in my early 20's, Paxil was completely effective in controlling panic attacks. I remember trying my damnedest to work myself into one and just failing at it, which was great.. it lost its efficacy rapidly, as most of those Prozac analogs do.. so at 80mg, we decided to switch to something else.. (Serzone, like a month before it was taken off the market.. lucky me on that one)

(Also Serzone did nothing anyway)

Celexa and Lexapro both were total placebo or less (acetaminophen effect)..

Effexor, hard to tell, by that time I was steadily on clonazepam. I would say it is effective for the slice of the pie that benefit from NARI. I've recently noticed Strattera actually reduces anxiety and Effexor was one of the few I was on for years.

Nothing really beat imipramine, strangely enough.

Imipramine and chlorpheniramine (chlor-trimeton) are possible in the top 5 effective A/Ds.. and one's OTC. Worth reading up on if you're treatment resistant. I can attest that it's a very good anxiolytic and you will get SSRI effects if you take it daily, regularly (roughly 8mg/day would be a starting dose)