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Old Dec 08, 2014, 04:00 AM
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nbritton nbritton is offline
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Member Since: Oct 2013
Location: Texas
Posts: 340
Quote:
Originally Posted by geis View Post
Deplin is the only medication that's ever touched my depression. It was a miracle drug for me, but I can't afford it on my extremely limited income.
Also, the BHMT (betaine—homocysteine S-methyltransferase) is a backup pathway to the folate-methionine-homocysteine cycle. Supplementing with trimethylglycine (a/k/a betaine) will activate this pathway, and essentially bypass the need for folate. The reason I mention this is because trimethylglycine can be purchased for as cheap as $0.07 a tablet; it's a by-product of sugar beet processing.

I would recommend tackling the problem from both sides, perhaps 1000 mcg of methylfolate combined with 1000 mg of trimethylglycine, this would get the costs down to $7 a month for you.

In the diagram below betaine is another name for trimethylglycine. DMG is dimethylglycine. BHMT takes trimethylglycine and converts homocysteine back into methionine by taking a methyl group from it. Dimethylglycine is leftover.


Last edited by nbritton; Dec 08, 2014 at 04:32 AM.