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Old Dec 10, 2014, 11:12 AM
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Sometimes psychotic Sometimes psychotic is offline
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Member Since: May 2013
Location: Chicago
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Discovery of novel drug target may lead to better treatment for schizophrenia

So pretty much every antipsychotic is a D2 inhibitor. In some of the GWAS studies there is a protein called DISC-1 that appears to be mutated in some patients. Apparently DISC-1 binds to and interacts with the D2 receptor and a chemical inhibitor of that interaction was found to have anti-psychotic properties. This is interesting to me because it may be a more direct target for some people but may help everyone and have a different side effect profile that may be gentler than straight out inhibiting dopamine.
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