Discovery of novel drug target may lead to better treatment for schizophrenia
So pretty much every antipsychotic is a D2 inhibitor. In some of the GWAS studies there is a protein called DISC-1 that appears to be mutated in some patients. Apparently DISC-1 binds to and interacts with the D2 receptor and a chemical inhibitor of that interaction was found to have anti-psychotic properties. This is interesting to me because it may be a more direct target for some people but may help everyone and have a different side effect profile that may be gentler than straight out inhibiting dopamine.