I've had at least 2 of my worst episodes while medicated, one of them consisted of soul deadening anhedonia, and some pretty bad ones I had off medication as well.
On meds I definitely was more symptomatic though, which is partially why I'm no longer on them. For a combination of reasons meds tend to make me more bipolar.
Meds aren't a cure, they're more like a safety net, a soft landing, because bipolar will continue to bipolar with or without them.
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DXD BP1, BPD & OCPD
"The best way to make it through with hearts and wrists in tact, is to realise, two out of three aint bad" FOB...
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