In my case -- and you'll see we all have different trials and errors -- after years of different antidepressants, I was on Wellbutrin for years and my anxiety was off the charts, so they kept increasing the klonopin to control it (barely). Finally, I got in to see a really good doctor at an actual mood disorder clinic. What a miracle. I'm not off the Wellbutrin and klonopin and on Lamictal. It, for me, is the best antidepressant I've ever been on and it has mood stabilizing properties as well. However, I have found that I can never take an antidepressant on it's own or I get really manic. I have to have an antipsychotic like Zyprexa on top of it. And Buspar for anxiety/worrying.