Hello InfiniteSadness: Unfortunately I have no experience with Gaba supplements. Have you tried searching the internet for information with regard to this? I did a quick search. On one website it did state that people with unipolar or bipolar depression should not take Gaba. There can also be interactions with medications. So it would be important to consult your prescribing physician if you're on med's. There is, from what I read, only anecdotal evidence suggesting that Gaba is beneficial. So it seems to me that, if you've been using Gaba & you're on med's you're taking something of a risk for potentially little or no benefit.