I hear your concern but I added Latuda before changing any of the other methods. It was effective pretty quickly and with only minor nausea as a side effect. (It is critical that you follow the food guidance, min of 350 calories).

It's definitely helped with the mood swings but I found I still need a (reduced) dose of Effexor to keep me out of the pit. The jury's still out but I'm hopeful I'm getting close to the right cocktail. I did not cope well with Wellbutrin at all and discontinued it after a few days.