I tried Effexor and it didn't help as an antidepressant. The only good thing was it killed my appetite and I didn't gain weight on it. The worse thing was it put me into a kind of stupor for most of the day, I was only really awake and alert for five hours in the evening, and the psychiatrist wouldn't help me. (This is a known side effect but unusual.) I came off of it myself, withdrawal very unpleasant.