Well...I'm not unmedicated now, although I only take Cymbalta. I'm not on a bunch of different stuff. However, from time-to-time, I have gone for long stretches unmedicated. It has typically gone along fine for a long time. Then, all of a sudden, I fall into self-harming behavior or a suicide attempt. I don't know why this happens. It just does. So, at this point, I just stay on the Cymbalta. It doesn't seem to help allot with my depression. But I think it keeps me from falling so low that I start self-harming, or worse.