Absolutely! I have dysthymia which not only slows my brain down but also crushes any desire to make any moves to help myself. 'I just don't feel like it' or 'I'm too tired to even think about it' or 'It's hopeless, so what's the point in trying', etc. I also have a strong sense of detachment from life, from emotions and from people in general. There's no joy in such an existence.