I personally don't believe you should resigned to the fact of always feeling depressed. I took flouxitine and it didn't help me but it works really well for others. I think it would be worth a try if your doctor agrees that it might help you.

I think we should always strive and hope for the better. I was in a deep depression for several years and just got better last September after a hospital stay and a complete change in medication, so there is always hope.