I'm on 800mg (400mg morning/400mg evening). I started at 25mg and slow titrated up to this level. I am no longer tired from it, not sure if it's the higher dose or I've gotten used to it. I don't really have any negative side effects. When I first started out I had a couple episodes where I almost passed out after standing up too fast (blood pressure side effect) but that went away.

I was on this for a couple months alone, then added prozac to it and I feel like I'm pretty decent with those two. I probably could get away with just taking the seroquel. If I miss a dose of seroquel I can feel it about 6 hours later. For instance, I forgot to take my morning dose yesterday and I had trouble going to sleep because of restless legs and mind racing. This morning I feel a bit more under control again.