Abilify was a lifesaver for me for depression. Tried multiple antidepressants over 20 years including Prozac, Paxil, Zoloft, Wellbutrin, Elavil and Effexor at maximum recommeded dosages, for anywhere from 2 mos to years. Also tried Lithium (really crappy side effects) for almost one year. No other medical problems (normal TSH, chemistry, CBC, vitamin levels). Only problem I seem to have with Abilify is cost and insomnia. I haven't slept through the night for five years. Up every night for 1-2 hours, at least once and sometimes twice. Slept like a baby before Abilify. I am currently on about 4 mg a day.