YES - When I went up, I got very clumsy and fell alot - I had to hold on tight to railings and was just very off balance. It was dangerous. I've had to stay on 150, BUT, I will say that I've been on Wellbutrin for probably 20 years, on and off, and I've gone up and down on it many times and the first 2 or three times I went up on it, I had no problems, so more than likely you'll be ok, but if you do have problems, clumsiness might be what to look out for.