Hey newgal2. Yes 25mg is no where near the target dose. My psychiatrist had me work up to 200mg and at first I was so frustrated bc I was taking those little 25s and was still depressed. But girl, once I got on about 100mg I noticed a drastic change. Took about a month. Felt like me again! Unfortunately I started abusing illegal substances and had a huge manic episode...fell off the wagon, so now im on 200mg seroquel. It helps, but its more like a tranquilizer. Stick with the lamictal, you know probably as well as I do that meds take about a month to build up in our systems. I wish u the best girl, keep ur head up.