Cambridge Journals Online - Psychological Medicine - Fulltext - Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis

One of the scariest things for me is that we know so little about what is going on in the brain either with psychosis or with antipsychotic use....there have been a number of studies showing a reduction in brain volume under both conditions....but this is the first I've seen showing an increase in parts of brain in this case the cortex.....I have to say it's somewhat reassuring that this is occurring in reponse to atypicals. It really makes me want to stay on my meds rather than take another trial off. Do you guys worry about the long term effects of the meds?