You said your "wife is one of my best friend and we go well together." If that is true, you need to do whatever it takes to repair your marriage. If you don't, the regret you live with for the rest of your life could be a living hell.

Your marriage is between you and your wife. Family members and friends have their input and that's okay, but ultimately it is you and your wife who have to live with whatever decisions are made.

I think you, as a couple, should postpone even thinking about a baby right now. Think about a baby in a year. For now, I strongly suggest you go to couple's therapy and work on strengthening your marriage, coping with the genetic disorder, and becoming as "well matured to face its consequences on us" as you are telling yourself you are. Best of luck to both of you~