I regularly use marijuana in conjunction with my psych meds to calm my hyper-sensitivity, irritability, lack of appetite, and insomnia. I use when depressed as well as manic. For me personally, smoking really helps with my depression, sort of makes all the crappiness more tolerable. When I'm on the manic end of the scale the weed helps keep me grounded and gives me an appetite so I can get food down. Definitely a good idea to go talk to dispensaries if they are available to you so you can get the right CBD/THC combo that works for you.