I used to take my meds AND drink and smoke to my heart's content. But at the time I was only on an antidepressant and Adderall...and Xanax.
Still, it ****ed me up good. I don't recommend that course of action. Bad, very, very bad. I'm sober now, which helps a whole lot.
So do yourself a favor and be honest. I'm at a point now where I'm confused as hell about my own ****, and a lot of that has to do with withholding information from my doctors.
Don't let yourself get stuck.