i often can tell when i need to take my meds and that is usually how i determine when to take them if i don't go by the clock. i just get very very anxious before i need them, a bit grumpy, and it takes awhile in the morning for them to kick in. i hate going through mornings they are the worst part of the day because i need my meds. i am a lifer on meds, i'll always need them, i found that out after several tries of going off of them and ending up in the pshyc wards. i don't mind because i value my sanity, one thing i don't have off of meds.