I have my tired spot in the morning and evening. It is all I can do to get out of bed in the morning and get to work on time. I used to be a morning person. I don't know if this has to do with depression or with the amitriptyline I take at night to prevent migraines. When I tried to stop the amitriptyline I got terrible migraines so I have to take this medicine. I also find I am fine energy wise until 8:30 at night. Then I am ready to crash in the bed. So I suppose my best energy level is right in the middle of the day.