I take Cymbalta for depression & fibromyalgia. I take 60 mg/day. I used to take 120 mg/day but I cut it back last year (took 5 months of tapering.)

I was interested in Fetzima because I read that its ratio of serotonin to norepinephrine er, involvement was much more slanted towards the NE than in the other SNRI drugs. I thought that would mean it was more helpful with pain at a lower dose.

I haven't tried it because of cost concerns.

Do you mind telling me what dosages of each you were one? I'm surprised the transition was so difficult.

I used to take Effexor ER before Cymbalta and switching from one to another was entirely smooth.

I'm just the opposite from you - I'm willing to put up with a fair amount of depression if my fibro pain is under control. Maybe your depression is just worse than mine. Mine used to be very painful, but now it's more blah, apathy, what housekeeping problem?