My two cents about weddings: they are all about the bride and groom, and not about the guests. A year from now they may - MAY - remember that you weren't there, but it's not likely. As for the reason, gosh, flat tire or other car problem, twisted ankle, cat threw up on your clothes. Anything. Unless you are a member of the wedding party, it's an event well worth skipping in order to stabilize.

Ymmv.