I know 2 things, it can make you retain fluid and over time "thin" your skin, my dad was on it for emphysema years before his death, his skin was so thin, the slightest scrape would tear it open, he also got bruise like marks on his hands. I was on it years ago for skin problems, caused me to gain 13lbs fuild buildup, and increased blood pressure. . .my next dermatologist gave me the option , use his treatment and get off the prednisone, it caused great depression too.
I do believe if it is prescribed for something more important than acne, it should be used according to doc's plans and monitoring.

DE