I gained 40 lbs on Depakote and then went on Seroquel at that time i changed my diet, a complete 180. My weight would not budge. Then I was diagnosed with hypothyroidism, got on meds lost 30 lbs, weight would not budge. I then came off of Seroquel because it caused me to be pre-diabetic and high triglycerides, I instantly dropped 30 lbs. Well I had to go back on Seroquel and I was scared of weight gain so my pdoc added topamax. I didn't lose weight but I didn't gain either, that insane craving for food was not there, just a little but no weight gain. Topamax made me stupid, so I recently came off of it. Well I started finding food wrappers on my nightstand. I freaked out, pdoc put me on a low dose of topamax and I seem to be doing better so far, but it's only been a week, so we'll see. Good luck, with the good comes the bad with these drugs.