I take 40 mg once a day. I can honestly say that it's the first medication that has actually helped with most of my symptoms. I have to take it at night with my trazidone because it does cause some akathisia. The first time I took it I got a serious rush where I just wanted to run around and dance. Which was like a miracle since I was so deep in a spiraling depression for months. It's definitely a game changer. It also almost completely cut out my anxiety!!! Good luck !!