I was on 200 mg of Lamictal for about 5 years & was bumped up to 300 about 9 mos. ago due to a sudden & severe episode (bipolar 1). I haven't had any side effects & it does seem to help with the depression. Also take Trazodone & klonopin to sleep. With other meds all combined, I do pretty well. Hope they work for you.--Suzy