My former psych nurse meds prescriber recommended using natural progesterone cream, so I do that. She recommended a brand called "Happy PMS" (gotta love the name, huh?) I've used about 3 different brands but like the consistency and scent and price of the Happy PMS brand best. I use it for facial moisturizer.

Sometimes I'll stop using it for a month or two and my impression is that I feel better when I use it. Hard to say for sure.