Yes, I've struggled with life-long anxiety, as well as depression & other stuff. It took me many decades to understand what was going on & to acknowledge this. I was on Cymbalta for the past 2+ years. I just recently went off due to cost considerations. I've noticed I'm considerably "sharper" now... also quicker to anger & more sarcastic. I don't plan to go back on med's though. I think I was more depressed on Cymbalta than I am off. So in sum, for me at this point, the decrease in anxiety I experienced while on this med was not really worth the dulling effect the med had on me...