Benadryl has never really has a sedative effect on me.

There is a "family joke" that I am allergic to marriage. I have been twice and suffered crazy panic attacks both times. Hives, tongue would swell, etc.. it was always attributed to "allergic reactions". One of the things my doc told me to do in the beginning was to take 4 benadryl, wait 20 mins. if no good, take 2 more, 20 mins, if still not settling down take 2 more and get a ride to the hospital. So through all of that the sedative effect kind of became non existent. BUT... I am imagining the Depakote may change that. So off to see the wizard, er.. a trip to the drug store is in order.