Hi topher-when in doubt check with your pdoc or pharmacist-I've been on Depakote for a couple of months now & was taking 250mg in am & 500mg at bedtime-last pdoc visit while discussing my ongoing struggle with insomnia & wanting to cut back to twice a week on ambien my pdoc suggested I try taking all my Depakote dose at bedtime which I have been doing now for about a week-sleeping really well now, ambien down to twice a week & other nights I take 1 melatonin & 2 Benadryl-btw if you take too much Benadryl it tends to make most people hyper & unable to sleep so be careful of that. Take care.