Pyroluria is a familial disorder which occurs with stress, where an above-average amount of a substance consisting of "kryptopyrroles" circulate in the body. The substance is harmless in itself, but high levels of these pyrrolles systemically bind with B6 and zinc, preventing the use of these essential nutrients in the brain and body. The root cause is the production of too much "kryptopyrrole" or "hemepyrrole" in the blood. A pyrrole is a chemical substance that is involved in the formation of heme, which makes blood red. Pyrroles bind with B6 and then with zinc, thus depleting these nutrients.
Pyroluria may occur along with other imbalances as seen in some subtypes of schizophrenia such as histapenia (low histamine), histadelia (high histamine), high copper levels or cerebral allergies. It is the primary imbalance for 20% of schizophrenics.

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