This is night #2 of the Seroquel. 2nd 50mg dose. Tomorrow I go up to 100mg. Pretty disappointed in the sedation qualities it has. PCP made it sound like I was going to be blowing saliva bubbles then unconscious for 12+hrs after taking it. Not so. I woke up quite a few times last night. Didn't feel like I slept any better than normal. I actually took a good long nap about 5 hrs after taking it. (not unusual for the weekend). So far not feeling any different really. As far as my mood goes today... pretty crappy actually. Very short and snappy w/ people. Nice and sweet to others... So far the rx gets a 1 out of 5 star rating.