gosh, i know exactly what you're going through. i've been on tons and tons of meds. they either don't work, work for a short time and fizz out on me, or only work partially. and, also, even add side effects like what i'm going through at this time. it sucks, especially when it makes me feel like a total retard. i'm a highly educated person, like a freaking scientist! oh yeah, i'm always doing research to find better ways to manage my condition. heh. biochemistry is funny thing, huh? anyway, i don't know what i can say other than that i totally sympathize with you. and i'm having similar problems that you have. i've been on prozac, lithium, elavil, zoloft, wellbutrin, paxil, desyrel, parnate, haldol, mellaril, effexor, remeron. now, i'm on cymbalta. i've had depression since 1992! dagnabbit, it sucks when nothing can get me out of the pit. but we got to hang in there, so we can make it to where something does work for us. i know it's a long journey, and painful. please don't let my post depress any of you. i don't know what the heck i'm saying because i'm stuck in a crazy fog.