Ive been on Topamax for about 6yrs, was on Ritalin with it, then went to Adderall, just switched to vyvanse last week. Now I'm taking the Topamax, vyvanse, celexa, and Seroquel. Too soon to tell if any negative effects from the vyvanse, but didn't notice any with the Adderall, other than it stopped working after about a year.
Good luck!