i have the very same issues, too. i'm taking cymbalta. my pdoc just took me off of klonapin, since he thinks it is the one causing me these side effects: exhaustion, excessive sleepiness, mental fog and confusion. any activity i do nowadays knocks me out like crazy. gosh, since i've been going off of klonapin, the side effects hasn't gone away. there were times when i felt sick with nausea when i finish an activity that's a bit physical. but, it hasn't happened in the last few days, though. by the next appointment with my pdoc, we'll know for sure if it's truly the cymbalta that's doing it. i'm an unusual case with my depression. i react to meds differently. it can be weird. so, i do understand what you're going through. i've had this fatigue for such a long time, and that's due to the depression, for sure.