I take the antidepressant Cymbalta (duloxetine) 60 mg daily for my fibromyalgia pain. It helps a lot. I still have lots of fatigue and sleep problems, though. Pristiq and high-dose Effexor ER (venlafaxine) (375 mg/day) also work.

I'm not sure what autoimmune disease you have. I have a type of autoimmune arthritis and have taken sulfasalazine, methotrexate, Enbrel, and Humira for it. I take Humira now. It works the best of any that I have taken, but it is very expensive. I'm not sure what country you're in, so I don't know if it's available to you or if it would work for the condition you have.

If you are getting joint swelling, please try to get a medication to stop this. You may already know this, but the swollen joint can stretch the ligaments and tendons around it then the joint won't function properly, even after the swelling goes down.

I found that my depression responded better to antidepressants after I got my autoimmune disease under control, too.