I have had depression for 50 years, many different meds and years of therapy. Finally decided to try again saw a pdoc and started lamictal to add onto the welbutrin and clonazapam I've been on for 3 yrs within 2 weeks I could tell a difference . I am 55 yrs old and have depression since a young child, I have been only mildly depressed for 6 months now. I am a different person and everything seems so much better. I am truly alive for the first time in my life. I think this saved me from a life of misery. Keep trying you never know what will work for you. Hope it doesnt take 50 yrs to find your right combination good luck