Hello.

I need to know which medicine will have a greater affect on the alpha-1 adrenergic receptors.

Do we know that the higher number means it would therefore have a greater affect?

Binding profile lists are from wiki.

Trazodone

Ki(nm)
α1A 153
α1B ND
α2A 728
α2B ND
α2C 155

Or Mirtazapine
Ki(nm)
α1A 500
α1B ND
α2A 20
α2B ND
α2C 18

If you are curious as to why I want to know this, I have a disease called POTS which is now believed to involve antibodies which act as alpha-1 antagonists. So it would then follow that being on an alpha antagonist (which both trazadone and remeron are) would not be ideal.

I really really appreciate any info, Thank you

P